Blood-brain barrier damage in vascular dementia
نویسندگان
چکیده
منابع مشابه
Peripheral markers of blood-brain barrier damage.
Neurological diseases are often associated with cerebrovascular dysfunction and changes in blood-brain barrier (BBB) function. This is important for two seemingly conflicting reasons. On the one hand, a leaky BBB may lead to brain disease by allowing extravasation of cells and molecules normally segregated in the periphery, while on the other hand an intact BBB may hamper drug delivery to the a...
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Clinical manifestations of methylmercury (MeHg) intoxication include cerebellar ataxia, concentric constriction of visual fields, and sensory and auditory disturbances. The symptoms depend on the site of MeHg damage, such as the cerebellum and occipital lobes. However, the underlying mechanism of MeHg-induced tissue vulnerability remains to be elucidated. In the present study, we used a rat mod...
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S troke is a major cause of death and long-term disability accompanied by steep social and medical costs. Diabetes mellitus (DM) is a chronic, lifelong, severe metabolic health problem characterized by hyperglycemia, attributable to insulin deficiency, insulin resistance, or a combination of both. Patients with DM suffer from massive vascular damage and rapidly develop microvascular and macrova...
متن کاملPeripheral markers of brain damage and blood-brain barrier dysfunction.
PURPOSE Occurrence of brain damage is frequently associated with abnormal blood-brain barrier (BBB) function. Two brain-specific proteins, S100beta and neuron-specific enolase (NSE) are released systemically in a variety of neurological diseases, but S100beta levels sometimes rise in the absence of neuronal damage, suggesting that S100beta is a marker of BBB rather than neuronal damage. METHO...
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Stroke is a complex vascular and neurological syndrome that can lead to death and disability [1]. About 15 million people worldwide [1] and 800,000 people in the United States suffer stroke each year [2]. On average, in the U.S. every 40 seconds someone has a stroke and every 4 minutes someone dies from a stroke [2]. This medical emergency has very limited treatments, and causes serious health ...
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ژورنال
عنوان ژورنال: Neuropathology
سال: 2015
ISSN: 0919-6544
DOI: 10.1111/neup.12262